Table 1 Identification of differentially expressed protein spots in 2D-DIGE analysis

From: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients

Spot No.	Protein name	Gene symbol	Gene map locus	Accession No.	Functional ontlogy^a			2D-DIGE^b		LC-MS/MS
Spot No.	Protein name	Gene symbol	Gene map locus	Accession No.	Molecular class	Molecular function	Biological process	FC^c	P-value^d	MASCOT score	Theoretical pI/m^e
1	Kinesin-like protein KIF11	KIF11	10q24.1	P52732	Motor protein	Motor activity	Cell growth/maintenance	1.20	0.004	93	5.47/119,158.99
2	Heat shock 70 kDa protein 4 L	HSPA4L	4q28	O95757	Heat shock protein	Heat shock protein activity	Protein metabolism	0.78	0.039	393	5.63/94,512.49
3	Heat shock protein HSP 90-beta	HSP90AB1	6p12	Q6PK50	Chaperone	Chaperone activity	Cell communication; Signal transduction	0.91	0.043	177	4.89/40,295.18
	Pyridoxal-dependent decarboxylase domain-containing protein 1	PDXDC1	16p13.11	Q86XE2	Enzyme: decarboxylase	Carboxy-lyase activity	Metabolism; Energy pathways			155	6.21/54,982.42
4	Vacuolar protein sorting-associated protein 35	VPS35	16q12	Q96QK1	Transport/cargo protein	Transporter activity	Transport	1.73	0.026	814	5.32/91,707.03
5	Interferon-induced GTP-binding protein Mx1	MX1	21q22.3	P20591	GTPase	GTPase activity	Cell communication; Signal transduction	1.13	0.050	1545	5.60/75,520.34
6	Interferon-induced GTP-binding protein Mx1	MX1	21q22.3	P20591	GTPase	GTPase activity	Cell communication; Signal transduction	1.14	0.009	1616	5.60/75,520.34
7	Interferon-induced GTP-binding protein Mx1	MX1	21q22.3	P20591	GTPase	GTPase activity	Cell communication; Signal transduction	1.20	0.018	1202	5.60/75,520.34
8	Plastin-2	LCP1	13q14.3	P13796	Calcium binding protein	Calcium ion binding	Cell communication; Signal transduction	0.86	0.046	1315	5.29/70,288.39
9	Histidyl-tRNA synthetase, cytoplasmic	HARS	5q31.3	P12081	Enzyme: ligase	Ligase activity	Protein metabolism	0.94	0.045	1322	5.72/57,410.51
10	Glutaredoxin-3	GLRX3	10q26	O76003	Unclassified	Molecular function unknown	Biological process unknown	0.92	0.040	446	5.31/37,432.03
11	Uroporphyrinogen decarboxylase	UROD	1p34	P06132	Enzyme: decarboxylase	Carboxy-lyase activity	Metabolism; Energy pathways	0.84	0.049	135	5.77/40,786.91
12	Inorganic pyrophosphatase	PPA1	10q11.1-24	Q15181	Enzyme: phosphohydrolase	Catalytic activity	Metabolism; Energy pathways	0.83	0.025	505	5.54/32,660.04
13	Annexin A5	ANXA5	4q26-q28; 4q28-32	P08758	Calcium binding protein	Calcium ion binding	Cell communication; Signal transduction	0.91	0.023	527	4.93/35,936.77
14	Microtubule-associated protein RP/EB family member 1	MAPRE1	20q11.1-11.23	Q15691	Cell cycle control protein	Protein binding	Cell communication; Signal transduction	0.87	0.003	238	5.02/29,999.08
	EF-hand domain-containing protein D2	EFHD2	1p36.21	Q96C19	Unclassified	Molecular function unknown	Biological process unknown			254	5.15/26,697.28
	Tubulin-folding cofactor B	TBCB	19q13.11-13.12	Q99426	Chaperone	Chaperone activity	Protein metabolism			244	5.06/27,325.53
15	Ubiquitin carboxyl-terminal hydrolase isozyme L1	UCHL1	4p14	P09936	Ubiquitin proteasome system protein	Ubiquitin-specific protease activity	Protein metabolism	0.53	0.013	164	5.33/24,824.34
16	Adenine phosphoribosyltransferase	APRT	16q24	P07741	Enzyme: ribosyltransferase	Transferase activity	Purine salvage	0.92	0.015	375	5.75/19,607.77
17	Ig mu chain C region	IGHM	14q32.33	P01871	Immunogloblin	Antigen binding	Immune response	1.48	0.031	496	6.35/49,306.59
18	Trifunctional purine biosynthetic protein adenosine-3	GART	21q22.1; 21q22.11	P22102	Enzyme: transferase	Ligase activity	Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	0.93	0.042	509	6.26/107,767.19
19	Elongation factor 1-gamma	EEF1G	11q12.3	P26641	Translation regulatory protein	Translation regulator activity	Protein metabolism	1.18	0.047	248	6.25/50,118.81
20	Beta-lactamase-like protein 2	LACTB2	8q22-22.3	Q53H82	Unclassified	Molecular function unknown	Biological process unknown	0.88	0.039	221	6.32/32,805.65
	Putative deoxyribonuclease TATDN1	TATDN1	8q24.13	Q6P1N9	Unclassified	Molecular function unknown	Biological process unknown			100	6.51/33,601.66

FC fold change
^aFunctional ontology: proteins were classified according to functional ontology using the Human Protein Reference Database (HPRD: http://www.hprd.org)
^b2D-DIGE: evaluation and normalization of protein spot intensities and statistical test were performed by PDQuest software
^cFC = the ratio of the average intensity (SCZ/CON)
^dP-value: the differentially expressed protein spots were determined by Student’s t-test
^eTheoretical isoelectric point (pI) and molecular mass (m) according to the sequence

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Table 1 Identification of differentially expressed protein spots in 2D-DIGE analysis

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