Table 1 Demographics of each group genotyped

From: Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment

Cohort

Group

N

Age

Females (%)

APOE ε4+ (%)

APOE ε4ε4 (%)

BDR

LOAD cases

302

83.0

146 (48.3)

196 (64.9)

39 (12.9)

Controls

137

84.0

68 (49.6)

49 (40.1)

2 (1.5)

ICOS

MCI Non-converters

73

76.0

21 (28.8)

31 (42.5)

4 (5.5)

MCI converters

49

79.0

26 (53.1)

23 (46.9)

4 (8.2)

  1. The late-onset Alzheimer’s disease (LOAD) cases and controls were recruited from the brains for dementia research (BDR) resource. The individuals with mild-cognitive impairment (MCI) were recruited from a single study in Southampton, UK; conversion to LOAD was identified after 36-month follow-up. LOAD cases were shown to harbour more APOE ε4+ individual than controls (p < 0.001), but no significant differences were observed between the proportion of females or age at death. MCI converters were shown to have a significantly higher proportion of females in comparison to the non-converters (p = 0.008), with no significant differences observed for age or APOE ε4+ carriers.
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