Table 1 Top 20 genes differentially expressed in PBMCs of tgDISC1 rats compared with littermate controls

From: Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia

 

Entry name

Gene symbol [rat]

Gene symbol [human]

Protein name

TG versus LM

qPCR performed

Change

FC

P

rat

human

1

RGS1_RAT

Rgs1

RGS1

Regulator of G-protein signaling 1

2.03

0.0062

Y

Y

2

CCL4_RAT

Ccl4

CCL4

Chemokine (C–C motif) ligand 4

1.67

0.0001

Y

Y

3

D4A8L8_RAT

Fpr2|Fpr2l

FPR2

Formyl peptide receptor 2 | Formyl peptide receptor 2-like

1.65

0.0053

n.d.

Y

4

CO3_RAT

C3

C3

Complement component 3

1.63

0.0037

Y

Y

5

Q9WVL9_RAT

Nkg7

NKG7

Natural killer cell group 7

1.60

0.0004

Y

Y

6

F1LRH7_RAT

Il12rb2

IL12RB2

Interleukin 12 receptor, beta 2

1.59

0.0095

Y

Y

7

ILEUA_RAT

Serpinb1a

SERPINB1

Serine proteinase inhibitor, clade B, member 1a

1.52

0.0071

Y

Y

8

Q5MPU9_RAT

Ly49si3

Immunoreceptor Ly49si2

1.51

0.0060

n.d.

n.d.

9

Q5M7T7_RAT

Pla2g7

PLA2G7

Phospholipase A2, group VII

1.48

0.0056

n.d.

n.d.

10

H2A2A_RAT

LOC690131|Hist2h2aa3

HIST2H2AA3

Similar to H2A histone family, member O | Histone cluster 2, H2aa3

1.47

0.0002

n.d.

n.d.

11

Q66HN6_RAT

Slc27a2

SLC27A2

Solute carrier family 27 (fatty acid transporter), member 2

1.46

0.0089

Y

Y

12

Q561K3_RAT

Il13ra1

IL13RA1

Interleukin 13 receptor, alpha 1

1.45

0.0074

Y

Y

13

CP4F3_RAT

Cyp4f18

CYP4F2

Cytochrome P450, family 4, subfamily f, polypeptide 18

1.44

0.0038

n.d.

n.d.

14

RL10_RAT

Rpl10

RPL10

Ribosomal protein L10

1.41

0.0059

n.d.

n.d.

15

D3ZPB4_RAT

Olr428

OR1L6

Olfactory receptor 428

1.41

0.0092

n.d.

n.d.

16

IFNG_RAT

Ifng

IFNG

Interferon gamma

1.38

0.0014

Y

Y

17

D1MF50_RAT

RGD

1561778

CD300C

Similar to dendritic cell-derived immunoglobulin-like receptor 1

1.38

0.0055

n.d.

n.d.

18

F1LYV1_RAT

Scimp

SCIMP

SLP adaptor and CSK interacting membrane protein

1.37

0.0018

n.d.

n.d.

19

TSN31_RAT

Tspan31

TSPAN31

Tetraspanin 31

1.36

0.0041

n.d.

n.d.

20

D4AC93_RAT

Tmem223

TMEM223

Transmembrane protein 223

1.35

0.0050

n.d.

n.d.

  1. Arrow down, reduced expression in tgDISC1 rats, arrow up, increased expression in tgDISC1 rats. FC fold change, qPCR quantitative real-time PCR, n.d. not determined, Y qPCR performed (yes), LM non-transgenic littermate control, TG tgDISC1 rat