Table 2 Bioinformatic analysis of the microarray data (Supplementary Table 6) by Gene Ontology/Panther (top panel) or ingenuity pathway analysis (bottom panel)
Gene Ontology/Panther 13.1. | Raw | |
|---|---|---|
Name | P | FDR |
Positive regulation of toll-like receptor signaling pathway | 1.14E-04 | 3.03E-02 |
Positive regulation of reactive oxygen species biosynthetic process | 1.30E-04 | 3.23E-02 |
Cytokine production involved in immune response | 2.08E-04 | 4.53E-02 |
Regulation of CD4-positive, alpha/beta T-cell activation | 6.38E-05 | 2.00E-02 |
Positive regulation of cytokine production | 1.16E-08 | 6.05E-05 |
Regulation of lymphocte proliferation | 4.05E-05 | 1.47E-02 |
Positive regulation of ERK1 and ERK2 cascade | 2.39E-04 | 4.80E-02 |
Ingenuity pathway analysis/top canonical pathways | ||
|---|---|---|
Name | P | Overlap |
Communication between innate and adaptive immune cells | 2.34E-05 | 4.3% 4/94 |
Role of hypercytokinemia in the pathogenesis of influenza | 6.15E-05 | 7.0% 3/43 |
Altered T-cell and B-cell signaling in rheumatoid arthritis | 5.52E-04 | 3.3% 3/90 |
Differential regulation of cytokine production in intestinal epithelial cells by IL17A and IL17F | 7.65E-04 | 8.7% 2/23 |
Natural killer cell signaling | 1.33E-03 | 2.5% 3/122 |
