Fig. 1: Hypothesis.
From: Testosterone imbalance may link depression and increased body weight in premenopausal women
We tested the association between a depressive symptomatology and overweight, b association between overweight and depressive symptomatology with sex hormone levels, and c whether the association between depression and overweight might be mediated through altered sex hormone levels associated with increased BMI. Step 1 in c shows an association between overweight (≥25 kg/m²) and depressive symptomatology (CES-D ≥ 23 points). Step 2 in c shows an association between overweight and sex hormone level and Step 3 in c shows an association between depressive symptomatology, overweight, and sex hormone level
