Table 2 mRNA expression of microglial genes in the medial frontal gyrus

From: Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated

 

Control

 

BD

 

Control

BD

Gene

Median

IQR

Median

IQR

p-value

Median

IQR

Median

IQR

p-value

AIF1

3.05

6.35

2.19

4.75

0.68

4.78

6.81

3.28

5.88

0.43

P2Y12

0.86

3.08

0.74

1.64

0.50

1.22

2.95

1.48

1.78

0.85

TMEM119

0.27

0.73

0.23

0.38

0.78

0.39

0.75

0.19

0.48

0.43

CD68

1.31

2.89

0.58

1.44

0.30

2.88

3.69

1.25

1.69

0.10

CX3CR1

1.76E−4

1.83E−4

8.61E−5

1.44E−4

0.10

2.93E−4

4.00E−4

1.23E−4

2.20E−4

0.15

ITGAM

0.06

0.14

0.06

0.09

0.47

0.08

0.19

0.11

0.13

0.85

IL1B

0.05

0.34

0.06

0.20

0.71

0.18

0.38

0.22

0.31

1.00

IL6

0.04

0.16

0.05

0.17

0.45

0.05

0.12

0.15

0.33

0.52

HLA-DRA

3.97

7.71

1.74

2.73

0.20

6.25

11.03

3.81

5.28

0.06

  1. mRNA expression was determined in grey (left) and white matter (right) of the medial frontal gyrus in patients with bipolar disorder (BD, N = 15) and controls (N = 16) by qPCR. Median, interquartile range (IQR; 25–75%) and p-value is shown for microglial-associated genes (AIF1, P2RY12, TMEM119), genes expressed on all myeloid cells (CD68, CX3CR1, ITGAM) and genes involved in (microglial) immune activation (IL1B, IL6, HLA-DRA)
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