Fig. 1: DEX-stimulated gene co-expression modules. | Translational Psychiatry

Fig. 1: DEX-stimulated gene co-expression modules.

From: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development

Fig. 1

Genes that were found to be significantly differentially expression between vehicle and 2.5 nM, 5 nM, and 50 nM of DEX (FDR < 5%), which were independent of PTSD status, were subjected to WGCNA analysis. A total of 21,117 genes were used as input. Seven modules were identified and an analysis of variance (ANOVA) was used to assess changes in module eigengene (ME) values with increasing concentration of DEX (p-values are labeled above each boxplot). Each module was subjected to gene ontology enrichment analysis and the top most significant enrichment terms and their associated Benjamini-Hochberg adjusted P-values are displayed. Further, we also display some of the top hub genes (kME > 0.6) within each module for quick interpretation of GR-stimulated gene co-expression modules and candidate individual genes.

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