Fig. 3: Identification of lithium-responsive genes associated with schizophrenia and Alzheimer’s disease. | Translational Psychiatry

Fig. 3: Identification of lithium-responsive genes associated with schizophrenia and Alzheimer’s disease.

From: Astrocytes are direct cellular targets of lithium treatment: novel roles for lysyl oxidase and peroxisome-proliferator activated receptor-γ as astroglial targets of lithium

Fig. 3

Lithium-responsive astroglial genes were interrogated to identify novel associations within the disease specific databases for schizophrenia and Alzheimer’s disease. GO analysis representing the biological pathways statistically altered in schizophrenia (a) and Alzheimer’s disease (b). Protein–protein prediction analysis and NEST analysis identifies MMP9, LOX and TGFB1 at the core of the networks for schizophrenia (ai) and Alzherimer’s disease (bi). (PPI enrichment p < 1.0e−16)

Back to article page