Fig. 1: NURR1-KO mice show an increased locomotor activity and impulsivity.
From: NURR1 deficiency is associated to ADHD-like phenotypes in mice
a Both WT (n = 9) and NURR1-KO (n = 7) mice were weighted before the tests. No major differences were detected in body weight between WT and NURR1-KO mice (Mann–Whitney U test, p = 0.07). Both WT (n = 9) and NURR1-KO (n = 7) mice were tested in the open field (OF, b–e) and cliff avoidance reaction test (CAR, f-g). b, c The OF analysis disclosed that NURR1-KO mice showed an increased distance travelled (t-test, p = 0.002) and velocity (t-test, p = 0.01) in comparison to their WT littermates. d The line plot shows distance moved (cm) as a function of 10-min bins, and the bar plot depicts the mean distance traveled (cm) per bin. Analysis revealed that genotype conditions (LMM, p = 0.0006) and time (LMM, p = 0.0001) significantly influences locomotor activity. e In the same behavioral test, NURR1-KO mice did not show an anxious phenotype indicated by the distance travelled in center compared with their WT littermates (t-test, p = 0.25). f The analysis of CAR test in WT and NURR1-KO mice displayed that the 85.7% of the NURR1-KO mice fell from platforms (gray box) during the 60 min observation against to the 11.1% of WT (Fisher exact test, p < 0.0001). g Time course of CAR impairment in WT and NURR1-KO mice was reported and about the totality (85.7%) of the NURR1-KO mice dropped from the platforms within 30 min
