Fig. 2: NURR1-KO mice do not show alteration in motor performance and coordination and anxiety-like behavior
From: NURR1 deficiency is associated to ADHD-like phenotypes in mice
Both WT (n = 9) and NURR1-KO (n = 7) mice were tested on the rota-rod (a, b) and in the elevated plus maze (EPM) test for 5 min (c–e). a The analysis revealed that time conditions (LMM, p < 0.0001) but not genotype (LMM, p = 0.47) significantly influences motor performance. b No differences were detected in the total latency during the 3 days of trials (t-test, p = 0.51). c, d NURR1-KO did not reveal anxiety levels higher than WT mice analyzing the frequency of the entries in the open arm (c t-test, p = 0.16) and the percentage of the time spent in the open arm (d Mann–Whitney U test, p = 0.34). e No differences were detected also in the number of total entries (t-test, p = 0.66)
