Fig. 5: MPH rescues the altered locomotor activity of NURR1-KO mice but not their impulsive behavior.
From: NURR1 deficiency is associated to ADHD-like phenotypes in mice
Both WT and NURR1-KO mice treated with vehicle (0.9% NaCl) or MPH (0.75 mg/kg) 1 h before were tested in the open field (OF, a, b) or cliff avoidance reaction (CAR, c, d) for 1 h. a, b The analysis disclosed that NURR1-KO mice treated with MPH show a rescue in their altered locomotor activity, in terms of distance travelled (a) (Kruskal–Wallis with Dunn’s post hoc test, df = 3, p = 0.03) and velocity (b) (Kruskal–Wallis with Dunn’s post hoc test, p < 0.0001, df = 3, p = 0.03). The NURR1-KO mice treated with MPH perform similarly to WT mice treated with vehicle and MPH (Kruskal–Wallis with Dunn’s post hoc test, vehicle distance travelled: p = 0.33, velocity: p = 0.29; MPH distance travelled: p = 0.39, velocity: p = 0.38). Number of mice tested for OF: 13 WT vehicle, 14 NURR1-KO vehicle, 9 WT MPH, 10 NURR1-KO MPH. c The analysis of CAR test displayed that NURR1-KO mice treated with MPH did not show a rescue in their impulsive behavior (Fisher exact test, p = 1). Gray box indicates the percentage of mice which fell from the platform. d Also the time course of CAR impairment in WT and NURR1-KO mice after the MPH administration was reported. Number of mice tested for CAR 11 WT vehicle, 13 NURR1-KO vehicle, 9 WT MPH, 10 NURR1-KO MPH
