Fig. 1: Increased compulsive- and anxiety-like behaviours are observed in TALLYHO/JngJ mice while compulsive behaviour correlates with blood glucose levels.
From: Converging evidence points towards a role of insulin signaling in regulating compulsive behavior
a TALLYHO/JngJ (TH) mice show increased compulsive behavior compared to SWR/J mice (the control strain), as seen in a decrease in the spontaneous alternation behavior (37.4 ± 6.8 vs. 62.3 ± 2.1% spontaneous alternation, n = 9 per strain, p = 0.006). b In addition, an increase in the number of repeated arm entries was observed in the TH mice (11.3 ± 4.0 vs. 1.48 ± 0.74% of the total arm entries being repeated arm entries, n = 9 per strain, p = 0.041). c No difference was observed between the two strains in compulsive marble burying (8.2 ± 1.7 vs. 10.1 ± 1.1 marbles buried, n = 9 per strain, p = 0.365). d In addition, TH mice display increased anxiety behavior: a trend was observed toward a TH mice spending less time in the center zone of the open field compared with SWR/J mice (204.6 ± 26.6 vs. 254.2 ± 16.5 s, n = 4 per strain, p = 0.174). e More importantly, TH mice spent less time in the open arms of the elevated plus maze (EPM), suggesting increased anxiety (3.8 ± 0.98 versus 23.7 ± 2.97 s, n = 7 [TH] and n = 9 [SWR/J], p = 0.000096). f Blood glucose levels were negatively correlated with spontaneous alternation behavior (r = −0.495, n = 18, p = 0.037)
