Fig. 2: Daily intraperitoneal injection of CDPPB in juvenile mutant mice has transient beneficial effects. | Translational Psychiatry

Fig. 2: Daily intraperitoneal injection of CDPPB in juvenile mutant mice has transient beneficial effects.

From: Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation

Fig. 2

a A trend of reduced synaptic mGluR5 in mutants (one-way ANOVA, P = 0.1707, n indicated in graph). b Schematic diagram of the CDPPB treatment protocol. The whole litter of mice from heterozygous breeding pairs was kept with their mother throughout the experiment. c Homozygous mutant mice had significantly better weight gain after drug treatment (two-way repeated measure ANOVA, group: F(3,490) = 6.59, P = 0.0012; no significant difference between +/+ and +/m. P < 0.001 for all other pairwise comparison between two groups. Number of mice (n) indicated in graph. Data collected from seven litters. d Same mice showed a trend of reduced injury when counted at postnatal day 26 in CDPPB-treated litters (P = 0.236). +/+, wild-type; +/m, heterozygotes; m/m, homozygous Lrrc7 mutant

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