Fig. 4: Deficiency in LRRC7 causes reduced dendritic arborization in the hippocampus. | Translational Psychiatry

Fig. 4: Deficiency in LRRC7 causes reduced dendritic arborization in the hippocampus.

From: Lrrc7 mutant mice model developmental emotional dysregulation that can be alleviated by mGluR5 allosteric modulation

Fig. 4

a Mutant pyramidal neurons in the hippocampus showed elongated dendritic spines (arrows). Secondary apical dendrites of neurons from the CA1 region were analyzed by Neurolucida software. Student's t-test, **P < 0.01. No. of dendrites analyzed indicated in graph; three mice per genotype. b Reduced dendritic complexity in mutant hippocampal neurons as shown by Sholl analysis (Genotype, two-way ANOVA: F(1, 864) = 309.5, ***P < 0.0001). c Reduced length and branching in both basal and apical dendrites in mutant pyramidal neurons as analyzed by Neurolucida software (Basal: total length, Student's t-test, ***P < 0.001; length per order, two-way ANOVA: genotype: F(1, 112) = 50.42, P < 0.0001; number of branch per order, genotype: F(1, 112) = 94.77, P < 0.0001; apical: total length, Student's t-test, ***P < 0.001; length per order, two-way ANOVA: genotype: F(1, 240) = 17, P < 0.0001; number of branch per order, genotype: F(1,240) = 33.21, P < 0.0001). Bonferroni post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001. Number of neurons in b and c: +/+, wild-type = 14; m/m, mutant = 15 from three mice each

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