Fig. 1: Increased volume of white matter tracts in the frontal brain of the BTBR mice during neonatal development. | Translational Psychiatry

Fig. 1: Increased volume of white matter tracts in the frontal brain of the BTBR mice during neonatal development.

From: Precocious myelination in a mouse model of autism

Fig. 1

a Comparison of mean volume of white matter tracts at P6, P8, and P10 between B6 and BTBR mice using MRI. Results revealed that fiber tracts in frontal brain regions of the BTBR mice had greater volume at P6, but the difference reduced over time in two out of three cases. n = 10 mice for each strain at each age. b Representative TEM images of the optic nerve from B6 or BTBR mice at P9, and quantification of axons with compact myelin in optic nerve at this age. Totally, 208 images from five B6 mice and 153 images from four BTBR mice were analyzed. Yellow arrows indicate examples of axons wrapped by compact myelin. c Distribution of axonal cross-section area across different size bins in B6 and BTBR optic nerve. Totally, 8951axons from four B6 mice and 10,182 axons from four BTBR mice were analyzed

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