Table 1 Neuropsychiatric CNV association with ADHD in Icelandic and Norwegian samples

From: Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder

Neuropsychiatric CNV loci tested

Iceland and Norway combined

Affected/control carrier frequency (%)a

OR (95% CI), P (FDR adjusted)b

1q21.1 distal—deletion

0.0788/0.0288

2.68 (0.92, 6.44), 0.054

1q21.1 distal—duplication

0.146/0.0454

3.44 (1.67, 6.52), 0.0020

2p16.3 (NRXN1)—deletion

0.101/0.0210

4.68 (1.82, 10.64), 0.0026

15q11.2—deletion

0.417/0.244

1.65 (1.11, 2.37), 0.016

15q13.3 (BP4 & BP4.5–BP5) deletionc

0.135/0.0194

5.97 (2.63, 12.6), 1.0 × 10−4

16p11.2 distal—deletion

0.0338/0.0177

2.19 (0.42, 7.29), 0.19

16p11.2 proximal-deletion

0.0788/0.0354

2.16 (0.75, 5.11), 0.14

16p11.2 proximal—duplication

0.191/0.0437

4.34 (2.27, 7.81), 9.1 × 10−5

16p12.1—deletion

0.101/0.0664

1.52 (0.63, 3.16), 0.26

16p13.11—duplication

0.293/0.129

2.12 (1.31, 3.27), 0.0035

17p12—deletion

0.0563/0.0288

2.20 (0.67, 5.66), 0.13

17q12—duplication

0.0675/0.0315

2.20 (0.76, 5.24), 0.14

22q11.21—deletion

0.135/0.0155

10.73 (4.66, 23.15), 1.8 × 10−6

22q11.21—duplication

0.248/0.100

2.24 (1.32, 3.63), 0.0042

  1. aThe affected and control carrier frequencies were calculated from the combined number of CNV carriers divided by the number of genotyped individuals in the Icelandic and Norwegian sample combined, before adjusting the counts for relatedness. For Icelandic and Norwegian population frequency separately, see Supplementary Table 3
  2. bThe Icelandic and Norwegian affected and control, carrier and non-carrier counts, were adjusted for relatedness with a correction factor (1.187 in Iceland and 1.033 in Norway) using the intercept from LD score regression41, rounded to the nearest integer, and then combined using the Cochran–Mantel–Haenszel χ2 test for count data. The P values were further adjusted by false discovery rate (FDR)
  3. cBP—break point
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