Fig. 2: D4R expression and dopamine affect methylation metabolites in CHO cells.
From: Methylation-related metabolic effects of D4 dopamine receptor expression and activation
Methylation metabolite levels (a Methionine, b SAM, c SAH, d Homocysteine, e SAM/SAH) were measured in wild-type (WT) CHO cells and CHO cells transfected to express D4.2R, D4.4R, and D4.7R. Cells were treated with dopamine (10 µM; 30 min) (D), or the D4R-selective antagonist L-745870 (100 nM; 60 min) (L) or their combination (DL) (n = 3). Data are expressed as mean ± SEM. Asterisks indicate significant differences from matched WT group (*p < 0.05, **p < 0.01). ^ indicates significant difference from untreated control group (C) (^p < 0.05, ^^p < 0.01)
