Fig. 5: Multiple signals generated by D4R-mediated PLM.
From: Methylation-related metabolic effects of D4 dopamine receptor expression and activation
a Increased interaction with other PSD-bound membrane proteins can restrict access of the D4.7R to substrate phospholipids, thereby restricting the efficiency of D4.7R-mediated PLM. b Within its membrane microenvironment, D4R-mediated PLM can modulate activities of other PSD-bound proteins, promoting Îł-frequency oscillations associated with attention. Vulnerability of the vitamin B12 cofactor in methionine synthase to oxidation makes D4R-mediated PLM highly sensitive to redox status. c D4R-mediated PLM can exert metabolic effects on redox and methylation status, which are thus coordinated with attention. Methylation-dependent epigenetic regulation of gene expression can link memory formation to attended information
