Fig. 2: Effects of rs12415800 and MDD diagnostic status on SIRT1 mRNA expression. | Translational Psychiatry

Fig. 2: Effects of rs12415800 and MDD diagnostic status on SIRT1 mRNA expression.

From: The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population

Fig. 2

a Association of rs12415800 with SIRT1 mRNA expression in the discovery Han Chinese amygdala sample (N = 65). The values on Y-axis were presented as 2–ΔΔCt. b Association of rs12415800 with SIRT1 mRNA expression in the replication Han Chinese amygdala sample (N = 72). The values on Y-axis were presented as 2–ΔΔCt. c Diagnostic analysis of SIRT1 mRNA expression in the peripheral blood of 50 first-episode drug-naive MDD patients versus 52 healthy controls from Han Chinese. The values on Y-axis were presented as 2–ΔΔCt. d Association of rs4746720 (in high LD with rs12415800) with SIRT1 mRNA expression in the blood samples. The values on Y-axis were presented as 2–ΔΔCt. Error bar represents ± SEM.

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