Fig. 5: Differential patterns of gene expression in response to prolonged isolation and confinement in SAS and IAS participants.

Proportion of differentially expressed genes between baseline conditions and day 30, day 150 and post-mission in securely attached participants (SAS) and insecurely attached participants (IAS). *p < 0.01 in the comparison between SAS and IAS subjects. Histograms have been obtained combining genes from “Oxidative phosphorylation”, “Mitochondrial” and “Sirtuin” pathways.