Table 2 Putative novel pharmacologic strategies to increase d-serine mediated NMDA receptor transmission as a means to treat anxiety-related disorders.

From: d-Serine as the gatekeeper of NMDA receptor activity: implications for the pharmacologic management of anxiety disorders

Target

Function

Pharmacologic manipulation

Asc-1 (Slc7a10)

d-Serine/amino acid exchanger

Activator116,147

ASCT1 (Slc1a4)

d-Serine/amino acid exchanger

Activator69

DAAO

Enzyme that breaks down d-serine

Inhibitor148,149,150

Serine racemase

Enzyme that converts l-serine to d-serine

Activator151

  1. Asc1 alanine-serine-cysteine-1 transporter, ASCT1 alanine/serine/cysteine/threonine transporter-1, DAAO d-amino acid oxidase.