Table 2 Effects of diagnosis, treatment and diagnosis × treatment on resting regional cerebral blood flow (rCBF) within neural circuits relevant for BN/BED (hypothesis-driven analysis).

Region-of-interest	Main effect of treatment			Main effect of diagnosis			Interaction treatment × diagnosis
Region-of-interest	F	P (uncorrected)	P (adjusted)	F	P (uncorrected)	P (adjusted)	F	P (uncorrected)	P (adjusted)
VTA	0.727	0.396	1.386	0.296	0.588	0.915	0.003	0.960	0.960
SN	1.400	0.240	1.680	0.027	0.871	1.016	0.006	0.939	1.095
Right Amy	0.154	0.696	1.624	4.231	0.043	0.120	0.008	0.927	1.179
Left amy	0.122	0.727	1.272	3.71×10^-4	0.985	0.985	0.282	0.596	1.192
PFC	1.979	0.163	2.282	7.462	0.008	0.028	0.107	0.744	1.302
Orbitofrontal	0.105	0.746	1.160	9.100	0.003	0.042	0.005	0.944	1.016
Insula right	0.058	0.811	1.032	7.854	0.006	0.028	0.970	0.327	1,526
Insula left	0.038	0.846	0.846	1.264	0.264	0.528	0.038	0.846	1.184
HPT	1.315	0.254	1.185	0.254	0.616	0.862	0.076	0.784	1.219
ACG	0.134	0.715	1.430	8.347	0.005	0.035	0.596	0.442	1.031
Dorsal striatum right	0.080	0.778	1.089	2.983	0.088	0.205	0.965	0.329	1.152
Dorsal striatum left	0.054	0.817	0.953	0.019	0.892	0.961	0.985	0.324	2.268
Acc right	0.304	0.583	1.632	0.657	0.420	0.735	0.802	0.373	1.044
Acc left	0.040	0.842	0.907	0.042	0.838	1.067	1.200	0.276	3.864

This table shows the results of a hypothesis-driven investigation of the effects of diagnosis, treatment and diagnosis × treatment on rCBF within 14 anatomical regions-of-interest suggested to be involved in BN/BED. We tested these effects in a liner mixed model, controlling for global grey-matter cerebral blood flow and BMI. Statistical significance was set to p < 0.05, after correction for multiple testing with the Benjamini–Hochberg procedure.
Acc accumbens, ACG anterior cingulate gyrus, Amy amygdala, PFC prefrontal cortext, HPT hypothalamus, SN substantia nigra, VTA ventral tegmental area.

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