Table 2 Results of the association analysis for common/rare variants in MTA cohort by (A) single- and (B) multiple-locus linear mixed models.
From: Mutations in sphingolipid metabolism genes are associated with ADHD
(A) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Chr | SNP | Position (hg19) | Gene | Marker information | Single-locus linear mixed model | |||||
Ref/Alt | MAF | CR | HGVS nomenclature | β (SEβ) | P value | PFDR | ||||
14 | rs74073730 | 88,429,817 | GALC | G/A | 0.016 | 1 | c.1072C > T/p.Leu358Leu | 0.52 (0.09) | 1.65 × 10−8 | 2.26 × 10−6 |
2 | rs4668077 | 169,439,848 | CERS6 | G/A | 0.251 | 1 | c.407 + 22016A > G/intronic variant | 0.11 (0.02) | 6.47 × 10−6 | 4.43 × 10−2 |
11 | rs35785620 | 6,415,704 | SMPD1 | G/A | 0.004 | 1 | c.1763C > A/p.Thr588Lys | 0.58 (0.17) | 6.6 × 10−4 | 3.01 × 10−2 |
1 | rs143078230 | 28,285,155 | SMPDL3B | T/C | 0.002 | 1 | c.556T > C/p.Tyr186His | 0.91 (0.29) | 1.95 × 10−3 | 5.0 × 10−2 |
1 | rs139609178 | 150,939,279 | CERS2 | G/A | 0.002 | 1 | c.801C > A/p.Val267Val | 0.91 (0.29) | 1.95 × 10−3 | 4.4 × 10−2 |
11 | rs200333847 | 61,646,921 | FADS3 | C/T | 0.002 | 1 | c.385G > A/p.Asp129Asn | 0.91 (0.29) | 1.95 × 10−3 | 3.8 × 10−2 |
6 | rs41273880 | 53,135,449 | ELOVL5 | T/C | 0.002 | 1 | c.779A > G/p.Tyr260Cys | 0.91 (0.29) | 1.95 × 10−3 | 3.3 × 10−2 |
(B) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Chr | SNP | Position (hg19) | Gene | Marker information | Multi-locus linear mixed model | |||||
Ref/Alt | MAF | CR | HGVS nomenclature | β (SEβ) | P value | PFDR | ||||
14 | rs74073730 | 88,429,817 | GALC | G/A | 0.016 | 1 | c.1072C > T/p.Leu358Leu | 0.47 (0.09) | 8.03 × 10−8 | 1.1 × 10−5 |
11 | rs35785620 | 6,415,704 | SMPD1 | G/A | 0.004 | 1 | c.1763C > A/p.Thr588Lys | 0.56 (0.15) | 1.6 × 10−4 | 5.6 × 10−3 |
1 | rs143078230 | 28,285,155 | SMPDL3B | T/C | 0.002 | 1 | c.556T > C/p.Tyr186His | 0.98 (0.25) | 1.01 × 10−4 | 6.9 × 10−3 |
1 | rs139609178 | 150,939,279 | CERS2 | G/A | 0.002 | 1 | c.801C > A/p.Val267Val | 0.98 (0.25) | 1.01 × 10−4 | 4.65 × 10−3 |
22 | rs13057352 | 47,095,235 | CERK | C/A | 0.027 | 1 | c.918G > T/p.Leu306Phe | 0.21 (0.06) | 1.51 × 10−3 | 3.45 × 10−2 |
