Fig. 4: Gestational exposure to nPM alters HMGB1 signaling from early development into adulthood. | Translational Psychiatry

Fig. 4: Gestational exposure to nPM alters HMGB1 signaling from early development into adulthood.

From: Adult mouse hippocampal transcriptome changes associated with long-term behavioral and metabolic effects of gestational air pollution toxicity

Fig. 4

a Principal component analysis and representative changes in 158 genes from HMGB1 signaling pathway in the hippocampus of young adult mice gestationally exposed to nPM. b Changes in HMGB1 signaling and some representative genes in the cerebral cortex of neonates that are gestationally exposed to nPM. Principal component analysis of 158 genes from the HMGB1 signaling pathway showed nPM is associated with changes in PC4 of the neonate cerebral cortex. c HMGB1 is among the initial responses in rat mixed glial culture after exposure to 10 μg/ml nPM for 24 h. HMGB1 response was TLR4 dependent, shown by siRNA knockdown (N = 3 per group, representative of two independent experiments). *FDR adjusted p-value < 0.05. The decrease of HMGB1 protein was correlated with the increase of inflammatory cytokines: (IL6, KC/GRO, TNFα, IL1ß, IL5) and decrease of IL4. The correlation analysis did not include groups with TLR4 knockdown. *p < 0.05.

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