Table 2 Genome-wide significant variants for each measure of cognitive function, their ancestry-specific allele frequency estimate, and replication in independent samples.

Test	Variant	chr	Position	Coded allele	Other allele	Coded allele frequency	N	Beta (se)	P-value	P-value (edu-adj)	Ancestry-specific allele frequency^a			Replication P-value^b
Test	Variant	chr	Position	Coded allele	Other allele	Coded allele frequency	N	Beta (se)	P-value	P-value (edu-adj)	Amerindian	European	African	Replication P-value^b
B-SEVLT	rs113719683	4	40433446	T	C	0.939	7562	0.6 (0.1)	3.70E-08	6.70E-08	0.997	0.926	1.000	0.800
	rs112178366	4	40433442	A	G	0.939	7562	0.6 (0.1)	4.06E-08	6.81E-08	0.997	0.927	1.000	0.709
	rs112927755	4	40433460	G	A	0.940	7562	0.6 (0.1)	4.32E-08	7.13E-08	0.997	0.927	1.000	0.775
WFT	rs59912956	3	69592250	GA	GAA	0.814	7446	1.0 (0.2)	5.09E-10	2.46E-09	0.815	0.828	0.805	0.434^c
WFT	rs568391433	6	33004530	C	CT	0.996	7446	−5.8 (1.0)	1.07E-08	5.09E-08	1.000	0.995	1.000	0.356^c
DSST	rs74610382	10	16254360	G	A	0.997	7372	10.8 (1.8)	5.04E-09	1.32E-06	1.000	1.000	0.985	0.330
	rs116623781	10	16226698	G	A	0.997	7372	10.3 (1.8)	5.05E-09	2.05E-06	1.000	1.000	0.984	0.310
	rs181182078	10	16260622	A	T	0.997	7372	10.7 (1.8)	5.94E-09	1.88E-06	1.000	1.000	0.985	0.658
	rs150206471	10	16220142	C	T	0.997	7372	10.4 (1.8)	7.44E-09	6.27E-07	1.000	1.000	0.984	0.327
	rs142289140	10	16264277	C	G	0.997	7372	10.5 (1.8)	8.31E-09	2.91E-06	1.000	1.000	0.985	0.786
	rs115696258	10	16270189	C	T	0.997	7372	10.5 (1.8)	1.11E-08	3.47E-06	1.000	1.000	0.986	0.379

^aEthnic groups used in replication were determined by estimated ancestry-specific allele frequency (in bold).
^bReplication P-values were generated by meta-analysis of ARIC, CARDIA and HRS. The direction of association with the effect allele for all variants are the same in the discovery and replication samples.
^cThe two variants for WFT were only observed in HRS so that the meta-analysis P-values were contributed solely by HRS. B-SEVLT brief Spanish English verbal learning test, WFT word fluency test, DSST digit symbol substitution test, chr chromosome, N sample size, SE standard error, edu-adj education adjusted, ARIC atherosclerosis risk in communities, CARDIA coronary artery risk development in young adults, HRS health and retirement study.

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