Table 1 PSL-IV individual item change scores post CO2 challenge.
Placebo | JNJ-61393215 25 mg of QD | Placebo | JNJ-61393215 90 mg of QD | Placebo | Alprazolam 1 mg of BID | |
|---|---|---|---|---|---|---|
Dizziness | 1.9 (1.08) | 1.3 (1.22) | 2.3 (1.06) | 1.8 (1.09) | 2.1 (0.92) | 1.7 (1.19) |
Choking/gasping for breath | 1.8 (0.83) | 1.9 (0.90) | 2.5 (1.38) | 1.8 (1.28) | 2.1 (0.92) | 1.9 (1.30) |
Hot flashes/cold shivers | 0.3 (0.75) | 0.3 (0.65) | 0.9 (1.56) | 0.5 (1.33) | 0.8 (1.25) | 0.2 (0.40) |
Nausea | 0.4 (0.51) | 0.2 (0.39) | 0.7 (1.23) | 0.5 (1.33) | 0.3 (0.61) | 0.1 (0.30) |
Palpitations | 1.9 (1.08) | 1.3 (1.15) | 1.8 (1.27) | 1.8 (1.28) | 1.9 (0.95) | 1.3 (0.90) |
Sweating | 0.7 (0.49) | 0.8 (0.94) | 1.3 (1.29) | 0.9 (0.86) | 1.3 (1.14) | 1.0 (0.89) |
Shortness of breath | 1.6 (1.00) | 1.8 (0.97) | 2.3 (1.15) | 2.1 (1.32) | 2.2 (0.89) | 1.9 (1.22) |
Numb/tingling | 0.8 (0.94) | 0.7 (1.07) | 1.5 (1.0) | 1.2 (1.36) | 0.9 (0.95) | 0.7 (0.79) |
Depersonalization/derealization | 0.5 (0.80) | 0.6 (0.79) | 1.2 (1.47) | 1.2 (1.41) | 1.1 (1.10) | 0.8 (0.98) |
Fear of dying | 0.1 (0.29) | 0.1 (0.29) | 0.3 (0.89) | 0.4 (1.12) | 0.3 (0.73) | 0.1 (0.30) |
Fear of losing control | 0.3 (0.65) | 0.3 (0.65) | 0.4 (0.90) | 0.4 (0.87) | 0.3 (0.61) | 0.4 (0.50) |
Chest pain discomfort | 0.3 (0.45) | 0.2 (0.39) | 0.8 (1.14) | 0.7 (1.18) | 0.1 (0.36) | 0 (0) |
Trembling/shaking | 1.3 (0.87) | 1.3 (0.97) | 1.6 (1.51) | 1.4 (1.39) | 1.1 (1.27) | 1.2 (1.54) |
