Table 4 Cerebrospinal fluid findings.

From: Cerebrospinal fluid, antineuronal autoantibody, EEG, and MRI findings from 992 patients with schizophreniform and affective psychosis

 

Total (N = 992)

Schizophreniform syndromes (N = 456)

Affective syndromes (N = 536)

Statistics

Cerebrospinal fluid basic parameters

WBC counts (Mean ± SD, range)

1.97 ± 4.85 (from 1 to 101/µl)

2.11 ± 6.46

1.84 ± 2.81

F = 0.228

p = 0.633

Increased WBC counts (ref. <5 /µl)

↑: 38 (4%)

↔: 944 (96%)

n.a.: 10

↑: 15 (3%)

↔: 439 (97%)

n.a.: 2

↑: 23 (4%)

↔: 505 (96%)

n.a.: 8

Wald = 1.771

p = 0.183

Protein concentration (Mean ± SD, range)

471.71 ± 238.71 (from 107 to 2890 mg/l)

459.75 ± 230.92

481.86 ± 244.89

F = 1.079

p = 0.299

Increased protein concentration (ref. < 450 mg/l)

↑: 448 ↑ (45%)

↔: 543 = (55%)

n.a.: 1

↑: 201 ↑ (44%)

↔: 254 = (56%)

n.a.: 1

↑: 247 ↑ (46%)

↔: 289 = (54%)

n.a.: 0

β = 0.341

Wald = 5.571

p = 0.018

Albumin quotients (Mean ± SD)

5.81 ± 3.18

5.64 ± 3.18

5.95 ± 3.19

F = 2.682

p = 0.102

Increased albumin quotients (ref.: <40y.: < 6.5 × 10-3; 40–60y.: <8 × 10−3; >60y.: <9.3 × 10−3)

↑: 174 ↑ (18%)

↔: 815 (82%)

n.a.: 3

↑: 85 ↑ (19%)

↔: 371 = (81%)

n.a.: 0

↑: 89 ↑ (17%)

↔: 444 = (83%)

n.a.: 3

Chi2 = 0.640

p = 0.424

IgG-Index (Mean ± SD)

0.50 ± 0.10

0.51 ± 0.11

0.50 ± 0.08

F = 0.566

p = 0.452

Number of patients with increased IgG indices (ref. <0.7)

↑: 19 (2%)

↔: 970 (98%)

n.a.: 3

↑: 8 ↑ (2%)

↔: 448 (98%)

n.a.: 0

↑: 11 ↑ (2%)

↔: 522 (98%)

n.a.: 3

Wald = 0.028

p = 0.866

Isolated OCB in CSF

40 (4%)

n.a.: 26

19 (4%)

n.a.: 7

21 (4%)

n.a.: 19

Wald = 0.029

p = 0.865

OCBs in CSF and Serum

52 (5%)

n.a.: 27

20 (4%)

n.a.: 7

32 (6%)

n.a.: 20

Wald = 1.915

p = 0.166

OCBs overall

93 (10%)

n.a.: 26

39 (9%)

n.a.: 7

54 (10%)

n.a.: 19

Wald = 1.084

p = 0.298

Cerebrospinal fluid overall variables

Inflammatory CSF changesa

Yes: 78/992 (8%)

No: 914 / 992 (92%)

34/456 (7%)

422/456 (93 %)

44/536 (8%)

492/536 (92%)

Wald = 0.198

p = 0.656

Overall basic CSF alterationsb

Yes: 492/992 (50%)

No: 500/992 (50%)

222/456 (49%)

234/456 (51%)

270/536 (50%)

266/536 (50%)

β = 0.336

Wald = 5.510

p = 0.019

  1. WBC white blood cell, ref. reference; n.a. not available; OCBs oligoclonal bands, CSF cerebrospinal fluid, SD standard deviation.
  2. aInflammatory CSF changes: WBC counts increased and/or IgG indices increased and/or CSF specific oligoclonal bands.
  3. bOverall basic CSF alterations: Inflammatory CSF changes and/or increased albumin quotients and/or increased protein concentrations. Abbreviations: WBC, white blood cell; ref., reference; n.a., not available; OCBs, oligoclonal bands, CSF, cerebrospinal fluid; SD, standard deviation.
  4. Significant p-values are marked in bold.
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