Table 3 Functional connectivity of the left dorsal caudate co-varying with oxytocin and left striatal dopamine transporter levels in healthy controls.

From: Dysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder

      

Peak coordinate

Direction

Region

Lateral

Cluster

BA

t score

x

y

z

Oxytocin levela

        

 Negative

Posterior parietal cortex

L

6206

7

5.04

−28

−48

56

 

Dorsolateral prefrontal cortex

L

141

10

3.95

−34

58

12

 

Lingual gyrus

L

348

18

4.42

−14

−72

−4

 

Lingual gyrus

R

298

19

4.06

16

−62

0

 

Superior occipital gyrus

R

161

19

3.96

18

−82

32

 Positive

Cerebellum (Crus II)

L

167

–

5.10

−32

−82

−42

Striatal DAT availabilityb

        

 Negative

Posterior parietal cortex

L

395

7

4.46

−24

−66

58

 Positive

Cerebellum (Crus II)

L

763

–

5.77

−14

−88

−38

 

Cerebellum (Crus II)

R

180

–

4.55

50

−60

−50

  1. Peak coordinates refer to the Montreal Neurological Institute (MNI) space. Significance was thresholded at the uncorrected voxel level p = 0.001, followed by the FWE-corrected cluster level p = 0.05.
  2. No correlation was found in the bipolar disorder (BD) II patients.
  3. BA Brodmann area.
  4. aFour BD II patients and eight controls did not have the plasma oxytocin level recorded and were excluded from this analysis.
  5. bTwo BD II patients did not undergo TRODAT and were excluded from this dopamine transporter (DAT) availability calculation.