Fig. 1: Cg27115863 is located in a putative regulatory region of the CARD10 gene. | Translational Psychiatry

Fig. 1: Cg27115863 is located in a putative regulatory region of the CARD10 gene.

From: Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: results from two longitudinal cohort studies

Fig. 1

Genome browser shot highlighting the genomic context of the Cg27115863 on Chromosome 22 (hg19/chr22:37921640–37921641). a The CpG is located approx. 6 kb proximal to the Transcription start site (TSS) of the CARD10 gene. GeneHancer tracks (Enhancer (gray) & Promoter (red), Interactions between regulatory Elements and Genes) indicate that Cg27115863 is located within a putative enhancer region of the CARD10 gene. b Zoom onto the GeneHancer element in which Cg27115863 is located. The CpG is located in a region of Transcription Factor binding sites indicated by the ENCODE ChiP-Seq track (161 Factors) with Factorbook Motifs (green)42,43,44. c Quantification of chromatin states of the Cg27115863 when active (State 1 – TssA) or inactive chromatin (State 13 – Repressed Polycomb, State 14 – Weak Repressed Polycomb, State 15 – Quiescent/low) marks where found at the TSS of CARD10 (hg19/chr22:37915549). The chromatin states (15 Primary Core Marks) of the Cg27115863 & TSS of CARD10 in 127 tissues/cells where obtained from the Roadmap Epigenomics project (http://www.roadmapepigenomics.org/). Active TSS states can appear at enhancer regions due the close proximity of the TSS & enhancers in the 3D structure of the genome.

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