Table 2 Results of multiple linear regression analysis of age at onset and number of major depressive and manic episodes associated with adverse childhood experiences and polygenic risk score (continuous variables).

Variables	Coefficient	SE	t	p
Age at onset^a
Number of ACE (CLES score)	–1.21	0.15	–7.86	<0.001**
BD–PRS	–0.68	0.30	–2.30	0.022*
Interaction	0.29	0.16	1.79	0.074
Number of manic episodes^b
Number of ACE (CLES score)	0.047	0.084	0.57	0.57
BD–PRS	−0.026	0.052	−0.50	0.62
Interaction	0.066	0.112	0.59	0.55
Number of depressive episodes^b
Number of ACE (CLES score)	−0.15	0.13	−1.11	0.27
BD–PRS	−0.12	0.082	−1.47	0.14
Interaction	−0.083	0.17	−0.48	0.63

CLES childhood life events scale, ACE adverse childhood experience, PRS polygenic risk score, BD bipolar disorder.
*p < 0.05, **p < 0.001.
^aAge at inclusion and sex were included as covariates in the analyses for age at onset.
^bAge at inclusion, age at onset, and sex were included as covariates in the analyses for number of episodes.

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