Table 4 Results of the multiple binary regression analysis of clinical outcomes associated with adverse childhood experiences and polygenic risk score (categorical variables).

From: Interaction between adverse childhood experiences and polygenic risk in patients with bipolar disorder

Variables

Coefficient

SE

df

p

History of psychotic featuresa

Number of ACE (CLES score)

0.056

0.042

1

0.18

BD–PRS

−0.11

0.077

1

0.15

Interaction

0.067

0.04

1

0.098

History of mixed symptomsa

Number of ACE (CLES score)

0.068

0.039

1

0.085

BD–PRS

−0.0008

0.074

1

0.91

Interaction

−0.006

0.041

1

0.89

History of suicide attemptsa

Number of ACE (CLES score)

0.18

0.039

1

<0001*

BD–PRS

−0.04

0.072

1

0.58

Interaction

−0.026

0.041

1

0.52

Presence of worsening in life functioninga

Number of ACE (CLES score)

0.26

0.062

1

<0.001*

BD–PRS

−0.15

0.094

1

0.12

Interaction

0.055

0.065

1

0.40

Presence of substance misusea

Number of ACE (CLES score)

0.13

0.04

1

<0.001*

BD–PRS

0.027

0.073

1

0.72

Interaction

−0.033

0.042

1

0.43

  1. CLES childhood life events scale, ACE adverse childhood experience, PRS polygenic risk score, BD bipolar disorder.
  2. aAge at inclusion, age at onset, and sex were included as covariates in the analyses for all clinical outcomes.
  3. *P < 0.001.
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