Fig. 2: Variant-pathways mapping. | Translational Psychiatry

Fig. 2: Variant-pathways mapping.

From: Immune response and endocytosis pathways are associated with the resilience against Alzheimer’s disease

Fig. 2

Locus: chromosome and position of the AD-associated genetic variants (coordinates are with respect to GRCh37). N. genes: total number of genes associated with each variant according to variant-gene mapping. Variant-gene mapping: Genes: all genes with at least one annotation to the five selected molecular pathways associated with AD. Weight: the weight of the variant-gene mapping. Gene-pathway mapping: immune response, beta-amyloid, endocytosis, cholesterol/lipid, angiogenesis: the weight of each molecular pathway at the gene level. Variant-pathway mapping: summarization of each variant’s effect after combining variant-gene and gene-pathway mappings. Red crosses indicate unmapped genes.

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