Table 1 Genetic main effects in Tcf4tg and Tcf4Ex4δ^+/− mice in different environments.

From: Modulation of cognition and neuronal plasticity in gain- and loss-of-function mouse models of the schizophrenia risk gene Tcf4

Superdomain	Domain	Measure	P_global	EE environment tg/wt			IR environment tg/wt			SD environment tg/wt			IR environment Tcf4δEx4/wt^†
Superdomain	Domain	Measure	P_global	Effect tg	Statistic	P	Effect tg	Statistic	P	Effect tg	Statistic	P	Effect Tcf4δEx4	Statistic	P
COGNITIVE DOMAIN		m	*	−0.127	t₈₀ = −0.438	0.663	−1.811	t₈₆ = −2.890	0.005	−1.997	t₈₂ = −4.372	<0.001	−1.632	t₈₆ = −3.723	<0.001
Spatial Learning		m	*	0.015	t₇₆ = 0.040	0.969	−4.103	t₈₂ = −2.397	0.019	−3.899	t₈₅ = −6.578	<0.001	−4.112	t₈₂ = −6.670	<0.001
	Initial learning	m	*	−0.093	t₅₀ = −0.128	0.899	−2.598	t₅₄ = −1.469	0.148	−3.035	t₅₆ = −3.378	0.001	−4.834	t₅₄ = −4.815	<0.001
	Flexibility learning	m	*	−0.621	t₅₀ = −0.849	0.400	−7.877	t₅₄ = −2.919	0.005	−4.698	t₅₆ = −6.020	<0.001	−6.862	t₅₄ = −4.632	<0.001
	Recall	m	*	0.645	t₅₀ = 1.210	0.232	0.002	t₅₃ = 0.004	0.997	−4.321	t₅₆ = −6.698	<0.001	−1.456	t₂₆ = −1.682	0.105
Fear memory		m	*	−0.413	t₅₄ = −0.939	0.352	−0.807	t₅₈ = −2.056	0.044	0.068	t₄₈ = 0.179	0.858	0.806	t₅₃ = 1.433	0.158
	Context memory	m	*	−0.417	t₅₂ = −0.830	0.410	−0.066	t₅₈ = −0.144	0.886	−0.318	t₂₃ = −1.129	0.271	0.763	t₄₆ = 1.512	0.137
	Cue memory	m	*	−0.467	t₅₂ = −0.729	0.469	−1.548	t₅₈ = −3.437	0.001	0.453	t₂₃ = 0.801	0.431	0.935	t₅₄ = 1.585	0.119
	Social fear memory	m	ns	–	–	–	–	–	–	1.153	t₅₆ = 2.099	0.040	–	–	–
Working memory	Working memory	u	*	0.104	t₂₆ = 0.175	0.863	0.439	t₂₈ = 0.581	0.566	−0.218	t₂₈ = −0.300	0.767	−2.032	t₂₈ = −2.666	0.013
AFFECTIVE DOMAIN		m	*	−0.922	t₁₁₀ = −3.359	0.001	−0.389	t₁₂₁ = −0.682	0.497	−0.159	t₈₈ = −0.537	0.593	−0.018	t₁₁₈ = −0.028	0.978
Pain sensitivity	Pain sensitivity	u	*	−1.032	t₂₆ = −0.935	0.358	−0.773	t₂₈ = −0.348	0.730	–	–	–	0.120	t₂₈ = 0.098	0.923
Anxiety	Anxiety	m	*	−0.492	t₅₄ = −1.251	0.216	−0.115	t₅₈ = −0.490	0.626	0.371	t₈₇ = 0.641	0.523	−0.829	t₈₃ = −1.271	0.207
Curiosity	Curiosity	m	*	−1.994	t₅₄ = −2.742	0.008	−1.560	t₅₈ = −1.238	0.221	−0.486	t₅₇ = −0.828	0.411	–	F_1.0,27.2 = 0.251	0.621
Motivation	Motivation	m	*	−0.246	t₅₄ = −0.403	0.689	0.115	t₅₉ = 0.086	0.932	−0.439	t₅₈ = −2.045	0.045	−0.142	t₅₃ = −0.287	0.775
ACTIVITY DOMAIN		m	*	−0.418	t₅₄ = −0.824	0.413	−0.224	t₆₀ = −0.266	0.791	0.163	t₅₈ = 0.560	0.577	0.490	t₅₈ = 1.070	0.289
Hyperactivity		m	*	−0.418	t₅₄ = −0.824	0.413	−0.224	t₆₀ = −0.266	0.791	0.163	t₅₈ = 0.560	0.577	0.490	t₅₈ = 1.070	0.289
	Ambulation	m	*	0.409	t₁₁₀ = 0.890	0.376	−0.768	t₁₁₉ = −0.919	0.360	0.776	t₁₁₇ = 1.205	0.231	0.447	t₁₁₃ = 0.832	0.407
	Speed	m	*	−1.238	t₅₂ = −1.553	0.127	−0.087	t₅₅ = −0.071	0.944	−0.413	t₅₆ = −1.180	0.243	0.380	t₅₆ = 0.944	0.349

Significant differences are marked in bold and with stars in the case of Pglobal. Numbers of degrees of freedom are marked for each statistic in subscript. Statistics depicted are from the multivariate analyses (see Supplementary Table 1 for all details).

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Table 1 Genetic main effects in Tcf4tg and Tcf4Ex4δ^+/− mice in different environments.

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