Table 2 The observations of race and sex-stratified EBF1 GxE (i.e., gene-by-stress or SNPxSTRESS) interactions with a hip circumference in the MESA data set.

From: Evaluating the precision of EBF1 SNP x stress interaction association: sex, race, and age differences in a big harmonized data set of 28,026 participants

Data set

Race

Sex

Mean age

N

Minor allele freq.

SNP beta

SNP P-value

GxE beta

GxE P-value

MESA

White

Both

62.68

2394

0.07

1.37

0.023

2.98

7.14E−09

MESA

White

Male

62.83

1153

0.06

0.24

0.740

0.34

0.624

MESA

White

Female

62.55

1241

0.07

2.38

0.012

4.42

7.97E−09

MESA

Black

Both

62.34

1575

0.02

−0.67

0.655

0.59

0.624

MESA

Black

Male

62.49

734

0.02

−2.20

0.286

0.59

0.764

MESA

Black

Female

62.21

841

0.02

0.88

0.680

−0.06

0.969

  1. GxE P-value is SNPxSTRESS interaction P-value, and SNP P-value is SNP main-effect P-value with no stress or interaction term in the model.
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