Table 2 rTMS effects on the helplessness profile.

From: Recovering from depression with repetitive transcranial magnetic stimulation (rTMS): a systematic review and meta-analysis of preclinical studies

Study

Intervention duration

Included in the meta-analysis

Other assessments

Timing

Test: parameter(s) used

Results

Timing

Test: parameter(s) used

Results

Chen et al. 201554

7 days

24 h after the last session

FST: immobility duration (s)

15 Hz: ↓ (=recovery)

   

Fang & Wang 201855

7 days

24 h after the last session

FST: immobility duration (s)

15 Hz: ↓ (=recovery)

24 h after the last session

FST: latency to immobility (s)

15 Hz: ↑ (=recovery)

FST: swimming duration (s)

15 Hz: ↑ (=recovery)

Feng et al. 201256

3 weeks

During the 1st week after the intervention

FST: immobility duration (s)

15 Hz: ↓ (=recovery)

During the 1st week after the intervention

FST: climbing duration (s)

15 Hz: ↑ (=recovery)

During the 3rd week after the intervention

FST: immobility duration (s)

15 Hz: ↓ (=recovery)

FST: climbing duration (s)

15 Hz: ↑ (=recovery)

Hargreaves et al. 200537

18 days

Immediately after the last session

FST: immobility duration (s)

20 Hz: ↓ (=improvement)

17 days after the first session

FST: immobility duration (s)

20 Hz: ns

Heath et al. 201838

4 weeks

24 h after the last session

FST: immobility duration as % of the pre-surgery value

10 Hz (0.004 T): ns;

10 Hz (0.05 T): ns;

10 Hz (1.0 T): ↑ (=recoverya)

   

Hedges et al. 200344

10 days

24 h after the last session

FST: swimming duration (s)

15 Hz: ns

Immediately after the last session

FST: swimming duration (s)

15 Hz: ↑ (=improvement)

3 days after the last session

15 Hz: ns

5 days after the last session

15 Hz: ns

7 days after the last session

15 Hz: ns

14 days after the last session

15 Hz: ns

Hesselberg et al. 201645

10 days

24/48 h after the last session

FST: immobility duration (s)

1 Hz: ↓ (=recovery);

20 Hz: ↓ (=recovery)

24/48 h after the last session

FST: struggling duration (s)

1 Hz: ↑ (=recovery);

20 Hz: ↑ (=recovery)

Keck et al. 200046

5 weeks

48 h after the last session

FST: immobility duration (s)

20 Hz: ↓ (=improvement)

48 h after the last session

FST: struggling duration (s)

20 Hz: ↑ (=improvement)

FST: latency to immobility (s)

20 Hz: ↑ (=improvement)

During the 2nd week after the intervention

FST: immobility duration (s)

20 Hz: ↓ (=improvement)

FST: struggling duration (s)

20 Hz: ↑ (=improvement)

FST: latency to immobility (s)

20 Hz: ↑ (=improvement)

Keck et al. 200147

10 days

24 h after the last session

FST: immobility duration (s)

20 Hz: ↓ (=recovery)

24 h after the last session

FST: struggling duration (s)

20 Hz: ↑ (=recovery)

FST: latency to immobility (s)

20 Hz: ↑ (=recovery)

FST: swimming duration (s)

20 Hz: ns

Kim et al. 200648

7 days

Immediately after the last session

FST: immobility duration (s)

10 Hz: ↓ (=improvement)

Immediately after the first session

FST: immobility duration (s)

10 Hz: ns

Peng et al. 2018b36

7 days

   

24 h after the last session

FST: immobility duration (%)

1 Hz (0.84 T): ns;

1 Hz (1.26 T): ns;

5 Hz (0.84 T): ↓ (=recovery);

5 Hz (1.26 T): ↓ (=recovery);

10 Hz (0.84 T): ↓ (=recovery);

10 Hz (1.26 T): ↓ (=recovery)

Sachdev et al. 200249

5 days

Immediately after the last session

FST: immobility duration (s)

1 Hz: ns;

5 Hz: ns;

15 Hz: ↓ (=improvement);

25 Hz: ↓ (=improvement)

12 h after the first session

FST: immobility duration (s)

1 Hz: ↓ (=improvement);

5 Hz: ↓ (=improvement);

15 Hz: ↓ (=improvement);

25 Hz: ↓ (=improvement)

48 h after the last session

 

1 Hz: ns;

5 Hz: ns;

15 Hz: ns;

25 Hz: ↓ (=improvement)

72 h after the first session

 

1 Hz: ↓ (=improvement);

5 Hz: ↓ (=improvement);

15 Hz: ↓ (=improvement);

25 Hz: ↓ (=improvement)

Sun et al. 201150

4 weeks

Immediately after the last session

FST: immobility duration (s)

10 Hz: ↓ (=recovery)

Immediately after the last session

FST: distance traveled (m)

10 Hz: ↑ (=recovery)

Tan et al. 201851

2 weeks

96 h after the last session

FST: struggling duration (s)

1 Hz: ↑ (=recovery)

96 h after the last session

FST: latency to immobility (s)

1 Hz: ↑ (=recovery)

Tsutsumi et al. 200239

10 days

24 h after the last session

FST: motor activity

15 Hz: ↑ (=improvement)

24 h after the first session

FST: motor activity

15 Hz: ns

Wang et al. 201457

7 days

24 h after the last session

FST: immobility duration (s)

15 Hz: ↓ (=recovery)

   

Wang et al. 201940

2 weeks

24 h after the last session

FST: immobility duration (s)

0.5 Hz: ↓ (=recovery)

8 days after the first session

FST: immobility duration (s)

0.5 Hz: ns

Xue et al. 201958

7 days

24/72 h after the last session

FST: immobility duration (s)

1 Hz: ns;

5 Hz: ↓ (=recovery)

   

Yang et al. 200741

10 days

24 h after the last session

FST: immobility duration (s)

15 Hz: Males: ↓ (=improvement); Females: ↓ (=improvement)

24 h after the last session

FST: latency to immobility (s)

15 Hz: Males: ↑ (=improvement);

Females: ↑ (=improvement)

FST: climbing duration (s)

15 Hz: Males: ↓; Females: ns

FST: swimming duration (s)

15 Hz: Males: ns;

Females: ↑ (=improvement)

Zyss et al. 199742

2 weeks

24 h after the last session

FST: immobility duration (s)

50 Hz: ↓ (=improvement)

   

Zyss et al. 199943

9/18 days

24 h after the last session

FST: immobility duration

(% of control sham)

20 Hz (300 s, 9 sessions): ns;

20 Hz (300 s, 18 sessions):

↓ (=improvement);

30 Hz (333 s, 9 sessions):

↓ (=improvement)

   
  1. Notes: Timing is referred to the rTMS intervention; recovery: recovery of the phenotype in models of disease; improvement: improvement of the behavioral profile in healthy models.
  2. FST forced swim test, ↓ ↑: statistically significant change, ns not significant.
  3. aOnly in this study an increase in immobility duration is indicative of recovery of the phenotype (attenuated psychomotor agitation). bNot included in the meta-analysis.