Table 3 Significant correlations of metabolites and RS connectivity between IBS and HC females.

From: Analysis of brain networks and fecal metabolites reveals brain–gut alterations in premenopausal females with irritable bowel syndrome

Metabolites

RS connectivity

r

p valuea

Histidine

Left PosDCgG to Left Pu

0.21

0.016

Cysteine

Left PosDCgG to Left Pu

0.19

0.030

Glycine

Left PosDCgG to Left Pu

0.17

0.043

Glutamate

Left PosDCgG to Left Pu

0.18

0.042

Spermidine

Left PosDCgG to Left Pu

0.17

0.050

Anserine

Left PosDCgG to Left Pu

0.18

0.040

Histidine

Right SupFG to Right Pu

0.20

0.022

Tryptophan

Right SupFG to Right Pu

0.17

0.050

Uracil

Right SupFG to Right Pu

0.22

0.010

2-Deoxyuridine

Right SupFG to Right Pu

0.19

0.027

Thymidine

Right SupFG to Right Pu

0.20

0.022

Succinate

Right SupFG to Right Pu

−0.19

0.029

  1. PosDCgG dorsal part of the posterior cingulate gyrus, SupFG superior frontal gyrus, Pu putamen.
  2. aPartial correlation analysis between metabolites and RS connectivity controlling for age, BMI, and diet was performed.
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