Table 2 Statistically significant results of the SBA analysis.
From: Synaptic processes and immune-related pathways implicated in Tourette syndrome
Gene set | SNPs | NSIG | ISIG | EMP1 | |||||
|---|---|---|---|---|---|---|---|---|---|
Chr | SNP | BP | A1 | F_A | F_U | A2 | P | OR | Genes implicated |
Ligand-gated ion channel signaling | 683 | 66 | 5 | 0.000267 | |||||
4 | rs1391174 | 46072596 | T | 0.4892 | 0.4586 | C | 1.764e−05 | 1.131 | GABRG1(0) |
5 | rs9790873 | 45291514 | C | 0.1535 | 0.1335 | T | 5.621e−05 | 1.177 | HCN1(0) |
9 | rs2259639 | 101317401 | T | 0.2751 | 0.2982 | C | 0.0003612 | 0.8928 | GABBR2(0) |
9 | rs1930415 | 101238974 | T | 0.2218 | 0.2424 | C | 0.0007006 | 0.8908 | GABBR2(0) |
11 | rs949054 | 120795888 | C | 0.2241 | 0.2053 | T | 0.001281 | 1.118 | GRIK4(0) |
Lymphocytes | 799 | 50 | 5 | 0.00035 | |||||
19 | rs16986092 | 55433696 | T | 0.1158 | 0.09473 | C | 1.093e−06 | 1.251 | NCR1(+9.257 kb)|NLRP7(−1.18 kb) |
13 | rs1933437 | 28624294 | G | 0.4183 | 0.3871 | A | 8.482e−06 | 1.138 | FLT3(0) |
3 | rs2243123 | 159709651 | C | 0.2515 | 0.2759 | T | 0.0001167 | 0.8817 | IL12A(0)|IL12A-AS1(0) |
7 | rs3801983 | 18683672 | C | 0.1928 | 0.2133 | T | 0.0003981 | 0.8808 | HDAC9(0) |
5 | rs2230525 | 66478626 | C | 0.08431 | 0.07127 | T | 0.0005641 | 1.2 | CD180(0) |
Cell adhesion and transsynaptic signaling | 3290 | 292 | 5 | 0.00107 | |||||
20 | rs1002762 | 58580885 | G | 0.2305 | 0.2028 | A | 2.031e−06 | 1.178 | CDH26(0) |
21 | rs2826825 | 22762779 | G | 0.376 | 0.3487 | A | 6.698e−05 | 1.126 | NCAM2(0) |
11 | rs7925725 | 131449365 | C | 0.3709 | 0.3979 | A | 0.0001099 | 0.8921 | NTM(0) |
11 | rs12224080 | 131816849 | G | 0.09841 | 0.08353 | A | 0.0002519 | 1.198 | NTM(0) |
3 | rs6773575 | 77060574 | C | 0.0964 | 0.1126 | A | 0.000256 | 0.8407 | ROBO2(0) |
