Fig. 4: Brain response to neutral faces in T-PRS-based LV1 regions as a mediator of the relationship between T-PRS and anhedonia. | Translational Psychiatry

Fig. 4: Brain response to neutral faces in T-PRS-based LV1 regions as a mediator of the relationship between T-PRS and anhedonia.

From: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms

Fig. 4

Brain response to neutral faces in T-PRS-based LV1 regions mediated the relationship between T-PRS and anhedonia in females (ab = 0.093, SE = 0.047, 95% CI [0.019; 0.198]) but not males (ab = 0.008, SE = 0.033, 95% CI [−0.061; 0.076]).

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