Fig. 2: CD36 knockout affects the gut microbiome compared with WT mice. | Translational Psychiatry

Fig. 2: CD36 knockout affects the gut microbiome compared with WT mice.

From: CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Fig. 2

a A Venn diagram of OTUs detected in WT and CD36−/− mice. b The majority of rarefaction curves tended to approach the saturation plateau. c Alpha-diversity analysis showed that CD36−/− mice were characterized by lower microbial richness (Chao, n = 8–9 mice/group, *P < 0.05) and higher microbial diversity (Simpson, n = 8–9 mice/group, *P < 0.05) relative to WT mice. d At the phylum level, partial least-squares discriminant analysis (PLS-DA) showed that gut microbiota composition in CD36−/− mice was greatly different from that in WT animals. e LEfSe identified the most differentially abundant taxons between WT and CD36−/− mice—(red) WT taxa; (blue) taxa enriched in CD36−/− mice. The brightness of each dot is proportional to its effect size. f Taxa enriched in CD36−/− mice are indicated with a positive LDA score (green), and taxa enriched in WT mice have a negative score (red). Only taxa meeting an LDA significance threshold >2 are shown.

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