Fig. 5: Genetic ablation of CD36 in mice alters the gut microbiota functional and the NLRP3/caspase-1 inflammatory pathway. | Translational Psychiatry

Fig. 5: Genetic ablation of CD36 in mice alters the gut microbiota functional and the NLRP3/caspase-1 inflammatory pathway.

From: CD36 deficiency affects depressive-like behaviors possibly by modifying gut microbiota and the inflammasome pathway in mice

Fig. 5

a Function prediction analysis by COG functional classification. b KEGG pathway enrichment of gut microbiota between the two groups (n = 8–9 mice/group, *P < 0.05). Genetic ablation of CD36 in mice alters the NLRP3/caspase-1 inflammatory pathway (c, d). c Hippocampal mRNA levels of NLRP3, ASC, pro-caspase-1 and caspase-1 in CD36−/− mice (n = 6–7 mice/group, P < 0.05). d Representative western blotting for hippocampal NLRP3, ASC, IL-1β, Cleaved-IL-1β, NF-кB, p-NF-кB, caspase-1 and pro-caspase-1 in CD36−/− mice (n = 5–7 mice/group, P < 0.05).

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