Fig. 1: Experimental approach and effects of paroxetine treatment on depression-like behavior. | Translational Psychiatry

Fig. 1: Experimental approach and effects of paroxetine treatment on depression-like behavior.

From: A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells

Fig. 1

A Schematic overview of the experimental schedules to assess the impact of paroxetine treatment on behavior (panel 1, n = 20) and dentate gyrus transcriptome profiles in comparison to vehicle-treated animals (panel 2, n = 13). To identify the molecular signatures underlying response, we stratified animals into good and poor treatment responder according to their behavioral outcome in the forced swim test (panel 3, n = 10 per subgroup good/poor responder). B Paroxetine treatment reduced immobility time (T test, t = 4.7, df = 18, p = 0.0002) in the FST in comparison to vehicle treatment. C Paroxetine treatment increased the time spent in the lit compartment of the LD box (T test, t = 2.2, df = 10, p = 0.0496). D Paroxetine plasma concentration was measured after treatment (Wilcoxon signed-rank test, p = 0.0313). FST forced swim test, LD light dark box, bars with mean and SEM. *p < 0.05; ***p < 0.001.

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