Fig. 3: Pathway analyses of response-associated transcripts. | Translational Psychiatry

Fig. 3: Pathway analyses of response-associated transcripts.

From: A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells

Fig. 3

A Upregulated response clusters: in a good vs poor responder comparison of dentate gyrus transcriptomes, we plotted all 117 upregulated genes and performed a kmeans clustering cluster analysis. We could detect two response-associated clusters (blue and green), and we showed their respective protein–protein interaction (PPI) profile (average local clustering coefficient: 0.304, PPI enrichment p value: <1.0e−16, n = 19). B Downregulated response clusters: in a good vs poor responder comparison of dentate gyrus samples, we plotted all 94 downregulated genes and performed a kmeans clustering cluster analysis. We could detect two response-associated clusters (blue and green) and we revealed their respective protein–protein interaction (PPI) profile (average local clustering coefficient: 0.528, PPI enrichment p value: <1.0e−16, n = 19). Insets show higher magnification of the most interesting clusters for improved visualization.

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