Fig. 4: Validation of genes differentially expressed between of good and poor responders. | Translational Psychiatry

Fig. 4: Validation of genes differentially expressed between of good and poor responders.

From: A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells

Fig. 4

A Paroxetine-treated animals and stratification in good and poor responder mice using the forced swim test (n = 90). B–L qPCR validation of 11 selected genes of interest (one-way ANOVA, Bonferroni’s Multiple Comparison Test). B Adamts1: F = 6.883, p = 0.0038. C AW551984: F = 3.917, p = 0.326. D Bmp5: F = 6.272, p = 0.0062. E Col1a1: F = 6.532, p = 0.0049. F Col1a2: F = 5.174, p = 0.0125. G Col3a1: F = 8.448, p = 0.0014. H Col6a1: F = 3.718, p = 0.0375. I Htr2c: F = 5.309, p = 0.0123. J Mcpt4: F = 12.39, p = 0.0002. K Otx2: F = 16.52, p < 0.0001. L Prl: F = 11.93, p = 0.0002. VEH vehicle, GR good responder, PR poor responder, bars with mean and SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

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