Fig. 5: Response-associated genes are regulated by glucocorticoid receptor activation. | Translational Psychiatry

Fig. 5: Response-associated genes are regulated by glucocorticoid receptor activation.

From: A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells

Fig. 5

A Schematic overview (n = 22). B–F qPCR of murine dentate gyrus samples revealed statistically significant upregulation of 5 genes (T test or Mann–Whitney test). B Otx2: t = 4.1, df = 18, p = 0.0006. C Htr2c: t = 3.3, df = 20, p = 0.0040. D Chrm5: t = 2.7, df = 14, p = 0.0182. E Oprm1: U = 3.0, p = 0.0003. F Hist1h2b: t = 2.8, df = 15, p = 0.0125. DEX dexamethasone, SAL saline, h hours, S sacrifice, bars with mean and SEM. *p < 0.05; **p < 0.01; ***p < 0.001.

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