Table 2 White matter regions with significant fractional anisotropy associations with dysphoria symptom change.

From: White matter anisotropy and response to cognitive behavior therapy for posttraumatic stress disorder

White-matter cluster	PTSD participants		Control participants		Correlation with change in dysphoria symptoms (R)	PTSD vs. control difference, %
	Mean FA	SD	Mean FA	SD
Limbic fibers
Left cingulum (cingulate gyrus)	0.63	0.07	0.64	0.04	−0.23	−0.76
Right cingulum (cingulate gyrus)	0.64	0.06	0.64	0.04	−0.099	0.68
Left fornix/stria-terminalis	0.56	0.06	0.55	0.05	−0.19	0.41
Right fornix/stria-terminalis	0.58	0.05	0.58	0.04	−0.132	0.24
Fornix body column	0.52	0.11	0.55	0.08	0.202	−3.55
Left uncinate fasciculus	0.58	0.07	0.57	0.05	−0.222	0.69
Right uncinate fasciculus	0.61	0.07	0.6	0.04	−0.141	0.42
Corpus callosum
Genu	0.76	0.07	0.77	0.03	−0.25	−0.54
Body	0.68	0.06	0.69	0.04	−0.152	−0.83
Splenium	0.82	0.06	0.82	0.03	−0.214	−0.19
Projection fibers
Left anterior corona radiata	0.54	0.06	0.53	0.03	−0.234	0.26
Right anterior corona radiata	0.55	0.05	0.55	0.03	−0.375	0.8
Left superior corona radiata	0.53	0.04	0.52	0.03	−0.279	0.73
Right superior corona radiata	0.53	0.05	0.53	0.03	−0.228	0.46
Left posterior corona radiata	0.57	0.04	0.55	0.03	−0.19	1.71^a
Right posterior corona radiata	0.55	0.04	0.54	0.03	−0.171	1.12
Left retrolenticular part of internal capsule	0.62	0.05	0.61	0.03	−0.196	0.9
Right retrolenticular part of internal capsule	0.63	0.06	0.62	0.03	−0.155	0.99
Left posterior thalamic radiation	0.65	0.06	0.65	0.03	−0.194	0.18
Right posterior thalamic radiation	0.66	0.06	0.66	0.04	−0.169	−0.61
Association fibers
Left sagittal stratum	0.6	0.05	0.59	0.03	−0.224	0.55
Right sagittal stratum	0.61	0.05	0.61	0.03	−0.133	−0.11
Left external capsule	0.54	0.05	0.54	0.03	−0.354	0.06
Right external capsule	0.52	0.05	0.52	0.03	−0.304	0.43
Left anterior limb of internal capsule	0.64	0.07	0.64	0.03	−0.335	−0.54
Right anterior limb of internal capsule	0.64	0.05	0.64	0.03	−0.427	0.53
Left posterior limb of internal capsule	0.71	0.07	0.7	0.03	−0.291	0.8
Right posterior limb of internal capsule	0.73	0.05	0.72	0.03	−0.272	0.92
Left superior longitudinal fasciculus	0.58	0.06	0.58	0.02	−0.216	−0.35
Right superior longitudinal fasciculus	0.56	0.05	0.56	0.03	−0.228	0.54
Left superior fronto-occipital fasciculus	0.54	0.06	0.55	0.05	−0.363	−0.02
Right superior fronto-occipital fasciculus	0.55	0.06	0.55	0.05	−0.13	0
Tracts in the brainstem
Left corticospinal tract	0.68	0.06	0.66	0.03	−0.185	1.99
Right corticospinal tract	0.66	0.05	0.67	0.04	−0.3	−1.18
Left cerebral peduncle	0.75	0.06	0.75	0.03	−0.226	−0.35
Right cerebral peduncle	0.75	0.06	0.75	0.02	−0.238	0
Left superior cerebellar peduncle	0.78	0.06	0.77	0.04	−0.162	1.4
Right superior cerebellar peduncle	0.73	0.06	0.73	0.03	−0.248	0.58
Middle cerebellar peduncle	0.72	0.08	0.72	0.03	−0.185	−0.34
Right medial lemniscus	0.69	0.06	0.7	0.03	−0.139	−0.3
Right inferior cerebral peduncle	0.62	0.07	0.61	0.04	−0.138	0.64
Pontine crossing tract	0.57	0.06	0.57	0.04	−0.444	0.33

^aIndicates significant difference between PTSD vs. Controls at p = 0.05.
R = correlation coefficient between fractional anisotropy and dysphoria symptoms change in the PTSD group (%).

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Table 2 White matter regions with significant fractional anisotropy associations with dysphoria symptom change.

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