Fig. 3: Distribution of the best models explaining variation in DNAm across the five cohorts.
From: Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Percentage of overlapping VMPs (n = 36,091) best explained by G, CA, G + CA, or G × CA in each cohort using the highest adjusted R2 For HBCS, 49.03% of VMPs presented with best model G × CA, 37.40% with best model G, and 13.55% with best model G + CA, and for BerlinLCS, 61.26% of VMPs presented with best model G × CA, 29.51% with best model G, and 8.75% with G + CA (a). Consistency of best model explaining DNAm variability in VMPs across five cohorts. Percentage of VMPs with the same model explaining variation in DNAm best overlapping between the cohorts stratified by model type (b).
