Fig. 1: Preclinical evaluation of [18F]FPEB binding after NAc challenge. | Translational Psychiatry

Fig. 1: Preclinical evaluation of [18F]FPEB binding after NAc challenge.

From: Study of influence of the glutamatergic concentration of [18F]FPEB binding to metabotropic glutamate receptor subtype 5 with N-acetylcysteine challenge in rats and SRM/PET study in human healthy volunteers

Fig. 1

A Preclinical NAc challenge study design: rats received either a water for injection (WFI) or a NAc (50mg/kg) tail injection 60 minutes before the scan, a 5 minutes transmission scan (CT) preceded the 61 minutes PET emission scan. Each animal was its own control, so that it underwent 3 imaging sequences for the whole protocol (test, retest and NAc challenge). B Mean [18F]FPEB Molar Activity (MA), mean injected Dose (ID) and Injected Mass (IM) per preclinical study condition.

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