Fig. 1: Enrichment analysis identifies m116 as the most microglia-related cortical gene co-expression module. | Translational Psychiatry

Fig. 1: Enrichment analysis identifies m116 as the most microglia-related cortical gene co-expression module.

From: A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Fig. 1

The normalized expression (FPKM) of genes in bulk DLPFC tissue (Y axis) are compared to their expression (FPKM) in isolated microglia (X axis). A hypergeometric test was used to assess for the extent of enrichment of m116 genes among the 1030 human microglial genes. Each dot represents one gene. Microglia-enriched genes (blue dots) were identified based on a fourfold higher expression in isolated microglia compared to bulk tissue. The microglia-enriched genes are likely involved in processes that are relatively specific to microglia. The genes in m116 are displayed in dark gray. Module 116 genes are more highly expressed in isolated microglia when compared to bulk tissue. FPKM fragments per kilobase of transcript per million mapped reads, DLPFC dorsolateral prefrontal cortex.

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