Fig. 2: Relationships between gene modules and Alzheimer’s disease traits. | Translational Psychiatry

Fig. 2: Relationships between gene modules and Alzheimer’s disease traits.

From: A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies

Fig. 2

The conditional dependencies between the expression level of modules and Alzheimer’s disease traits in the 540 ROSMAP participants are illustrated in (a) a heatmap and (b) a network diagram. In (b), a module or a trait is considered to be a node in the network, and these nodes are connected by lines (edges) if there is evidence that they are associated, after accounting for the behavior of all other modules and traits using partial correlation analysis. c Graphical summary of mediation analyses which propose that m5 increased expression precedes the accumulation of Tau which then leads to cognitive decline. All three factors are correlated to one another. On the inner aspect of each edge, we report the P value and effect size of the direct association of two traits, which are listed. The outer aspect of each edge presents the results of the model with the third variable included. The dotted edge denotes the fact that the association of m5 and cognitive decline is no longer significant once we adjust for the burden of Tau pathology. This suggests the order of events as being m5→Tau→cognitive decline. All regression models also include RIN and PMI. mod module, CogDec cognitive decline, NP neuritic plaques, DP diffuse plaques, NFT neurofibrillary tangles, RIN RNA integrity number.

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