Table 1 Enrichment of gene co-expression modules for microglia-related genes.
Module | MIcroglia enrichment P value | Number of genes in the module | Number of microglia genes in the module | AD genes | Microglia genes associated with cognitive decline | Pathways |
|---|---|---|---|---|---|---|
M116 | 2.30E-152 | 224 | 149 | TREM2, INPP5D | INPP5D, UNC13D, CMTM3, SPP1, TGFBI, RHOG, ACSL1, RPS6KA1 | Positive regulation of immune response, leukocyte activation, adaptive immune response, leukocyte-mediated immunity, response to interferon-gamma |
M115 | 8.60E-17 | 232 | 44 | TNFRSF12A, SPATA13, SHMT1, TGIF1, ITGA5 | Inflammatory response, regulation of response to wounding, cellular response to cytokine stimulus, cytokine-mediated signaling pathway, response to external biotic stimulus | |
M5 | 1.30E-14 | 431 | 58 | BIN1, PVRL2 | TRABD, PLXNB2, GMIP | Regulation of JUN kinase activity, regulation of adaptive immune response, leukocyte-mediated immunity, negative regulation of inflammatory response |
M113 | 1.80E-05 | 313 | 31 | CLU, SPPL2A, SQSTM1, MPZL1, ETS1 | ZFP36L1 | Anchoring junction, adherens junction, focal adhesion, cell-substrate adherens junction, cell-substrate junction, wound healing |
M114 | 3.00E-05 | 276 | 28 | SCAMP2, FCGRT, POLD1, NINJ1, COLGALT1, IRAK1, NFKBIA, TSPO | Positive regulation of NF-kappaB transcription factor activity, recycling endosome membrane, cellular response to lipopolysaccharide, cellular response to molecule of bacterial origin, nucleotide-binding oligomerization domain-containing signaling pathway |
